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KMID : 0882419930450020277
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Korean Journal of Medicine
1993 Volume.45 No. 2 p.277 ~ p.282
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A Case of Pulmonary Hypersensitivity Reaction Associated with Etodolac
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김종혁
정기석/박희봉/송숙희/김동규/이명구/김호중/현인규/류지소
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Abstract
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arious kinds of drugs including nonsteroidal antiinflammatory drugs (NASIDs) have been identified as causative agents of pulmonary hypersensitivity reaction.
Etodolac (diethy-tetrahydropyrano-indole-acetic acid) is a member of the indole/indene
acetic acid class of NSAIDs which also includes indomethancin and sulindac.
We experienced a case of pulmonary hypersensitivity reaction in 40 year-old male patient
who had developed sudden cough, dyspnea and fever after administration of etodolac. Physical
examination revealed scattered fine inspiratory crackles on both lower lungs and chest
radiograph showed bilateral diffuse reticulonodular infiltrates with left pleural effusion. He
was completely recovered in a week after discontinuation of the drug. But he was
readmitted with same clinical manifestation after inadvertent use of the same drug.
Withdrawal of etodolac again resulted in rapid improvement of his symptoms and signs
in few days. Therefore, we suggest that etodolac should be classified as one of the etiologic
agents which can elicit pulmonary hypersensitivity reaction.
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